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KMID : 0894520110150030197
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Development & Reproduction
2011 Volume.15 No. 3 p.197 ~ p.204
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Production of Intracellular Calcium Oscillation by Phospholipase C Zeta Activation in Mammalian Eggs
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Yoon Sook-Young
Kang Da-Won
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Abstract
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Egg activation is a crucial step that initiates embryo development upon breaking the meiotic arrest. In mammalian, egg activation is accomplished by fusion with sperm, which induces the repeated intracellular Ca2+- increases ([Ca2+]2 oscillation). Researches in mammals support the view of the [Ca2+]2 oscillation and egg activation is triggered by a protein factor from sperm that causes [Ca2+]2 release from endoplasmic reticulum, intracellular [Ca2+]2 store, by persistently activation of phosphoinositide pathway. It represents that the sperm factor generates production of inositol trisphosphate (IP3). Recently a sperm specific form of phospholipase C zeta, referred to as PLCZ was identified. In this paper, we confer the evidence that PLCZ represent the sperm factor that induces [Ca2+]2 oscillation and egg activation and discuss the correlation of PLCZ and infertility.
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KEYWORD
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Mammalian oocyte activation, Fertilization, Phospholipase C zeta
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